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Blisters, common skin nuisances caused by friction, burns, or allergies, usually heal naturally within weeks. Dermatologists advise against popping them to avoid infection. Clean the area, apply petroleum jelly, and cover with a bandage. While aloe vera or honey may soothe, they aren't as effective as petroleum jelly. Prevention includes well-fitted shoes and moisture-wicking socks. Diabetics should be cautious.